Flavonoid dimers are highly potent killers of multidrug resistant cancer cells overexpressing MRP1.

Abstract

MRP1 overexpression in multidrug-resistant cancer cells has been shown to be responsible for collateral sensitivity to some flavonoids that stimulate a huge MRP1-mediated GSH efflux. This massive GSH depletion triggers the death of these cancer cells. We describe here that bivalent flavonoid dimers strikingly stimulate such MRP1-mediated GSH efflux and… (More)
DOI: 10.1016/j.bcp.2016.10.013

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