Flavonoid binding to a multi-drug-resistance transporter protein: an STD-NMR study

@article{Nissler2004FlavonoidBT,
  title={Flavonoid binding to a multi-drug-resistance transporter protein: an STD-NMR study},
  author={Ludwig Nissler and R. Gebhardt and S. Berger},
  journal={Analytical and Bioanalytical Chemistry},
  year={2004},
  volume={379},
  pages={1045-1049}
}
Flavonoids are well known to inhibit the function of the multi-drug-resistance (mdr) transporter by interacting with their ATP binding domains. The precise orientation of these molecules inside the ATP binding pocket is still unclear. We applied the saturation transfer difference (STD) NMR technique to investigate the binding of the flavonoid luteolin and its 7-O-β-D-glycopyranoside to the recombinant nucleotide binding domain (NBD2) of mouse-mdr. First, this NMR technique confirmed binding of… Expand
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