Flavonoid apigenin inhibits motility and invasiveness of carcinoma cells in vitro.

  title={Flavonoid apigenin inhibits motility and invasiveness of carcinoma cells in vitro.},
  author={Jaroslaw Czyz and Zbigniew Madeja and Uwe Irmer and Wlodzimierz Korohoda and Dieter F. H{\"u}lser},
  journal={International journal of cancer},
  volume={114 1},
Investigations of the mechanisms of the cancer-preventive activity of apigenin (4',5,7,-trihydroxyflavone), a plant-derived, anti-carcinogenic flavonoid, showed its interference with cell proliferation, survival, and gap junctional coupling. We used a model based on non-invasive HeLa wild-type cells and their connexin43 (Cx43) transfected counterparts to correlate the effect of apigenin on tumour cell invasiveness with its influence on cell motility. Both cell lines displayed similar motile… CONTINUE READING

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