Flavones induce neutrophil apoptosis by down-regulation of Mcl-1 via a proteasomal-dependent pathway

@inproceedings{Lucas2013FlavonesIN,
  title={Flavones induce neutrophil apoptosis by down-regulation of Mcl-1 via a proteasomal-dependent pathway},
  author={Christopher D. Lucas and Keith C. Allen and David A Dorward and Laura J. Hoodless and Lauren A. Melrose and John A. Marwick and Carl S. Tucker and Christopher Haslett and Rodger Duffin and Adriano G Rossi},
  booktitle={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2013}
}
Neutrophil apoptosis and subsequent nonphlogistic clearance by surrounding phagocytes are key to the successful resolution of neutrophilic inflammation, with dysregulated apoptosis reported in multiple human inflammatory diseases. Enhancing neutrophil apoptosis has proresolution and anti-inflammatory effects in preclinical models of inflammation. Here we investigate the ability of the flavones apigenin, luteolin, and wogonin to induce neutrophil apoptosis in vitro and resolve neutrophilic… CONTINUE READING

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