Flavones and Flavonols may have Clinical Potential as CK2 Inhibitors in Cancer Therapy

@inproceedings{Mccarty2015FlavonesAF,
  title={Flavones and Flavonols may have Clinical Potential as CK2 Inhibitors in Cancer Therapy},
  author={M. Mccarty},
  year={2015}
}
The serine-threonine kinase CK2, which targets over 300 cellular proteins, is over expressed in all cancers, presumably reflecting its ability to promote proliferation, spread, and survival through a wide range of complementary mechanisms. Via an activating phosphorylation of Cdc373, a co-chaperone which partners with Hsp90, CK2 prolongs the half-life of protein kinases that promote proliferation and survival in many cancers, including Akt, Src, EGFR, Raf-1, and several cyclin-dependent kinases… Expand
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