Flavohemoglobin Hmp protects Salmonella enterica serovar typhimurium from nitric oxide-related killing by human macrophages.

@article{Stevanin2002FlavohemoglobinHP,
  title={Flavohemoglobin Hmp protects Salmonella enterica serovar typhimurium from nitric oxide-related killing by human macrophages.},
  author={T{\^a}nia M. Stevanin and Robert K. Poole and Eric A. G. Demoncheaux and Robert C Read},
  journal={Infection and immunity},
  year={2002},
  volume={70 8},
  pages={4399-405}
}
Survival of macrophage microbicidal activity is a prerequisite for invasive disease caused by the enteric pathogen Salmonella enterica serovar Typhimurium. Flavohemoglobins, such as those of Escherichia coli, Salmonella, and yeast, play vital roles in protection of these microorganisms in vitro from nitric oxide (NO) and nitrosative stress. A Salmonella hmp mutant defective in flavohemoglobin (Hmp) synthesis exhibits growth that is hypersensitive to nitrosating agents. We found that respiration… CONTINUE READING

4 Figures & Tables

Connections & Topics

Mentioned Connections BETA
Most significantly , hmp mutants internalized by primary human peripheral monocyte - derived macrophages survived phagocytosis relatively poorly compared with similarly bound and internalized wild - type cells .
Most significantly , hmp mutants internalized by primary human peripheral monocyte - derived macrophages survived phagocytosis relatively poorly compared with similarly bound and internalized wild - type cells .
All Topics