Flavogenomics – a genomic and structural view of flavin‐dependent proteins

@article{Macheroux2011FlavogenomicsA,
  title={Flavogenomics – a genomic and structural view of flavin‐dependent proteins},
  author={Peter Macheroux and Barbara Kappes and Steven E. Ealick},
  journal={The FEBS Journal},
  year={2011},
  volume={278}
}
Riboflavin (vitamin B2) serves as the precursor for FMN and FAD in almost all organisms that utilize the redox‐active isoalloxazine ring system as a coenzyme in enzymatic reactions. The role of flavin, however, is not limited to redox processes, as ∼ 10% of flavin‐dependent enzymes catalyze nonredox reactions. Moreover, the flavin cofactor is also widely used as a signaling and sensing molecule in biological processes such as phototropism and nitrogen fixation. Here, we present a study of 374… Expand
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