Flavoenzyme-mediated reduction reactions and antitumor activity of nitrogen-containing tetracyclic ortho-quinone compounds and their nitrated derivatives

Abstract

Nitrogen-based tetracyclic ortho-quinones (naphtho[1'2':4.5]imidazo[1,2-a]pyridine-5,6-diones, NPDOs) and their nitro-substituted derivatives (nitro-(P)NPDOs) were obtained by condensation of substituted 2,3-dichloro-1,4-naphthoquinones with 2-amino-pyridine and -pyrimidine and nitration at an elevated temperature. The structural features of the compounds… (More)
DOI: 10.17179/excli2017-273

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@inproceedings{PeiukaitytAlksn2017FlavoenzymemediatedRR, title={Flavoenzyme-mediated reduction reactions and antitumor activity of nitrogen-containing tetracyclic ortho-quinone compounds and their nitrated derivatives}, author={Milda Pe{\vc}iukaitytė-Alksnė and Jonas {\vS}arlauskas and Lina Misevi{\vc}ienė and Audronė Marozienė and Narimantas K. {\vC}ėnas and Kastis Krik{\vs}topaitis and Zita Staniulytė and Žilvinas Anusevi{\vc}ius}, booktitle={EXCLI journal}, year={2017} }