Flaviviridae Replication Organelles: Oh, What a Tangled Web We Weave.

  title={Flaviviridae Replication Organelles: Oh, What a Tangled Web We Weave.},
  author={David Paul and Ralf Bartenschlager},
  journal={Annual review of virology},
  volume={2 1},
Replication of positive-strand RNA viruses occurs in tight association with reorganized host cell membranes. In a concerted fashion, viral and cellular factors generate distinct organelle-like structures, designated viral replication factories. These virus-induced compartments promote highly efficient genome replication, allow spatiotemporal coordination of the different steps of the viral replication cycle, and protect viral RNA from the hostile cytoplasmic environment. The combined use of… CONTINUE READING
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