Flavin-containing monooxygenase mediated metabolism of psychoactive drugs by human brain microsomes
@article{Bhamre1995FlavincontainingMM, title={Flavin-containing monooxygenase mediated metabolism of psychoactive drugs by human brain microsomes}, author={Shubhada Bhamre and Shripad V. Bhagwat and Susarla Krishna Shankar and Michael R. Boyd and Vijayalakshmi Ravindranath}, journal={Brain Research}, year={1995}, volume={672}, pages={276-280} }
44 Citations
Cerebral Metabolism of Imipramine and a Purified Flavin-Containing Monooxygenase from Human Brain
- Biology, MedicineNeuropsychopharmacology
- 1996
Interindividual differences of human flavin-containing monooxygenase 3: genetic polymorphisms and functional variation.
- BiologyDrug metabolism and disposition: the biological fate of chemicals
- 2002
Human FMO3 may be another example of an environmental gene that participates in a protective mechanism to help humans ward off potentially toxic exposure of chemicals.
Characterization and modulation by drugs of sheep liver microsomal flavin monooxygenase activity
- Biology, ChemistryCell biochemistry and function
- 2005
Sheep liver microsomal FMO‐catalysed methimazole oxidation was inhibited by imipramine and chlorpromazine when these drugs were used at high concentrations and FMO activity was found to increase with the addition of detergents to the reaction medium.
Mammalian flavin-containing monooxygenases: structure/function, genetic polymorphisms and role in drug metabolism.
- BiologyPharmacology & therapeutics
- 2005
Flavin-containing monooxygenase mediated metabolism of benzydamine in perfused brain and liver.
- Biology, ChemistryBiochimica et biophysica acta
- 1998
methimazole by bovine liver microsomal flavine monooxygenase : modulation by imipramine and chlorpromazine , comparison with sheep enzyme
- Biology, Chemistry
- 2009
This is the first study to show the metabolism of methimazole by bovine liver microsomal flavin monooxygenase, and results obtained in this study are compared to those obtained previously with sheep enzyme.
In vitro metabolism of imipramine by brain microsomes: effects of inhibitors and exogenous cytochrome P450 reductase
- Biology, ChemistryBrain Research
- 1996
Hepatic Flavin-Containing Monooxygenase 3 Enzyme Suppressed by Type 1 Allergy-Produced Nitric Oxide
- Biology, MedicineDrug Metabolism and Disposition
- 2017
Type 1 allergic mice had differentially suppressed F MO3-dependent BDZ N-oxygenation, which is expected to alter FMO3-metabolic capacity–limited drug pharmacokinetics in humans.
References
SHOWING 1-10 OF 25 REFERENCES
Cerebral flavin-containing monooxygenase-mediated metabolism of antidepressants in brain: immunochemical properties and immunocytochemical localization.
- Biology, MedicineThe Journal of pharmacology and experimental therapeutics
- 1993
Immunocytochemical examination of rat brain sections using the above antibody revealed the preferential localization of flavin-containing monooxygenase in the neuronal cell body of brain microsomes, of profound pharmacological significance.
Evidence for the presence of distinct flavin-containing monooxygenases in human tissues.
- Biology, MedicineArchives of biochemistry and biophysics
- 1990
Xenobiotic metabolism in human brain — presence of cytochrome P-450 and associated mono-oxygenases
- BiologyBrain Research
- 1989
Recent studies on the structure and function of multisubstrate flavin-containing monooxygenases.
- BiologyAnnual review of pharmacology and toxicology
- 1993
Recent work on the number of isoforms present in major organs of entry, possible methods for estimating substrate specificity and activity of different isoforms in crude tissue preparations, and methods for manipUlating hepatic concentration (activity) of flavin-containing monooxygenases with dietary xenobiotics are focused on.
Human pharmacogenetics of nitrogen oxidations
- Biology
- 1991
Drug and foreign compound biotransformations are mediated by a group of enzymes known collectively as the ‘drug-metabolizing enzymes’, which mediate the oxidation of xenobiotic compounds and many of them also have a known physiological role.
Presence of flavin-containing monooxygenase in rat brain.
- Chemistry, BiologyBiochemical pharmacology
- 1991
Catalytic activity and immunohistochemical localization of flavin-containing monooxygenase in rat kidney.
- Biology, MedicineLife sciences
- 1993
Tissue- and species-dependent expression of multiple forms of mammalian microsomal flavin-containing monooxygenase.
- Biology, MedicineMolecular pharmacology
- 1987
The findings show that the expression of flavin monooxygenase isozymes is tissue and species dependent.
Rabbit lung flavin-containing monooxygenase. Purification, characterization, and induction during pregnancy.
- Biology, MedicineMolecular pharmacology
- 1985
The results demonstrate that, at least in rabbit, flavin-containing monooxygenase can exist as more than a single form.
Dimethylaniline N-oxidase and aminopyrine N-demethylase activities of human liver tissue.
- ChemistryXenobiotica; the fate of foreign compounds in biological systems
- 1973
N-Oxidation of N,N-dimethylaniline and oxidative demethylation of aminopyrine were studied in human liver hornogenates and neither activity was preferentially influenced by a specific disease process, but both decreased upon severe tissue damage.