Flavin-containing monooxygenase activity in hepatocytes and microsomes: in vitro characterization and in vivo scaling of benzydamine clearance.

@article{Fisher2002FlavincontainingMA,
  title={Flavin-containing monooxygenase activity in hepatocytes and microsomes: in vitro characterization and in vivo scaling of benzydamine clearance.},
  author={Michael B. Fisher and Kwansik Yoon and M Louette Vaughn and Timothy J Strelevitz and Robert S. Foti},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2002},
  volume={30 10},
  pages={1087-93}
}
Liver microsomes, and more recently cryopreserved hepatocytes, are commonly used in the in vitro characterization of the metabolism of new xenobiotics. The flavin-containing monooxygenases (FMO) are a major non p450 oxidase present in liver microsomes and hepatocytes. Since FMO is known to be thermally labile, and this enzyme may be involved in the metabolic clearance of some drugs, we sought to more completely characterize the metabolic competency of this enzyme in cryopreserved hepatocytes… CONTINUE READING
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