Flavin-containing monooxygenase 3 as a potential player in diabetes-associated atherosclerosis

  title={Flavin-containing monooxygenase 3 as a potential player in diabetes-associated atherosclerosis},
  author={J C Miao and Alisha V. Ling and Praveen V. Manthena and Mary E. Gearing and Mark J. Graham and Rosanne M. Crooke and Kevin J. Croce and Ryan M. Esquejo and Clary B Clish and David Vicent and Sudha B Biddinger and Esther Torrecilla and Gumersindo Fern{\'a}ndez V{\'a}zquez and Miguel Angel Rubio and Lucio Cabrerizo and Ana Barabash and Andr{\'e}s S{\'a}nchez Pernaute and Antonio J. Torres},
  booktitle={Nature communications},
Despite the well-documented association between insulin resistance and cardiovascular disease, the key targets of insulin relevant to the development of cardiovascular disease are not known. Here, using non-biased profiling methods, we identify the enzyme flavin-containing monooxygenase 3 (Fmo3) to be a target of insulin. FMO3 produces trimethylamine N-oxide (TMAO), which has recently been suggested to promote atherosclerosis in mice and humans. We show that FMO3 is suppressed by insulin in… CONTINUE READING
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Hepatic insulin signaling is required for cholesterologenic gene expression

J Miao
J. Lipid Res • 2014