Flavanone absorption after naringin, hesperidin, and citrus administration.

  title={Flavanone absorption after naringin, hesperidin, and citrus administration.},
  author={B Ameer and R A Weintraub and Jodie V. Johnson and Richard A. Yost and Russell Lee Rouseff},
  journal={Clinical pharmacology and therapeutics},
  volume={60 1},
Disposition of citrus flavonoids was evaluated after single oral doses of pure compounds (500 mg naringin and 500 mg hesperidin) and after multiple doses of combined grapefruit juice and orange juice and of once-daily grapefruit. Cumulative urinary recovery indicated low bioavailability ( < 25%) of naringin and hesperidin. The aglycones naringenin and hesperitin were detected in urine and plasma by positive chemical ionization-collisionally activated dissociation tandem mass spectrometry (PCI… CONTINUE READING


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