Flatworm asexual multiplication implicates stem cells and regeneration

@article{Reuter2004FlatwormAM,
  title={Flatworm asexual multiplication implicates stem cells and regeneration},
  author={M. Reuter and N. Kreshchenko},
  journal={Canadian Journal of Zoology},
  year={2004},
  volume={82},
  pages={334-356}
}
The phenomenon of asexual multiplication is rare in the animal kingdom, but it occurs in all main flatworm taxa. In the present paper, we review data regarding the presence of different forms of asexual multiplication in flatworms and argue that the presence of a population of totipotent or pluripotent stem cells, "neoblasts", is a primitive feature of decisive importance for the developing potential of flatworms. Next we present information on the role of stem cells in fission, head… Expand
The unique stem cell system of the immortal larva of the human parasite Echinococcus multilocularis
TLDR
Although the germinative cells are very similar to the neoblasts of other flatworms in function and in undifferentiated morphology, their unique gene expression pattern and the evolutionary loss of conserved stem cells regulators suggest that important differences in their physiology exist, which could be related to the unique biology of E. multilocularis larvae. Expand
Echinococcus multilocularis as an experimental model in stem cell research and molecular host-parasite interaction
  • K. Brehm
  • Medicine, Biology
  • Parasitology
  • 2009
TLDR
The combined input of data from the E. multilocularis genome sequencing project, stem cell cultivation, and recently initiated attempts to genetically manipulate Echinococcus will provide an ideal platform for hypothesis-driven research into cestode development in the next years. Expand
Stem cell proliferation during in vitro development of the model cestode Mesocestoides corti from larva to adult worm
TLDR
Proliferative cells have a characteristic localization and morphology throughout development from larva to adult of Mesocestoides corti, which is similar, and probably evolutionary conserved, to that described in other model cestodes. Expand
Transfection of Platyhelminthes
TLDR
In this review, availability of transfection techniques is analyzed across flatworms, from the initial transient achievements to the stable manipulations now developed for free-living and parasite species. Expand
Regeneration in Macrostomum lignano (Platyhelminthes): cellular dynamics in the neoblast stem cell system
TLDR
Double-labeling of neoblasts with bromodeoxyuridine and the anti-phospho histone H3 mitosis marker has revealed a complex cellular response in the first 48 h after amputation, different from that known to occur during regeneration in triclad platyhelminths and in starvation/feeding experiments in M. lignano. Expand
Regeneration of planarians: Experimental object
TLDR
This review aims to demonstrate the relevance and diversity of research conducted on simple biological objects—planarians—to a wider audience to show the historical continuity of these studies and their wide geographical distribution and to focus on the studies carried out in Russia. Expand
A new approach for the characterization of proliferative cells in cestodes.
TLDR
A reproducible flow cytometry and cell sorting method is developed to quantify and isolate the proliferating cells in the tetrathyridia larvae of the model cestode Mesocestoides corti, based on the DNA content of the cells. Expand
Stem Cells in Asexual Reproduction of Marine Invertebrates
TLDR
An overview of agametic cloning in the marine animal kingdom is presented and it is proposed that the levels of stem cell potential held in the tissue can have large consequences for the reproductive life cycle strategies and long-term fitness in clonal animals and strains. Expand
Evolutionary developmental biology (evo-devo) of cestodes.
  • U. Koziol
  • Biology, Medicine
  • Experimental parasitology
  • 2017
TLDR
A panoramic view is given of classical aspects, methods and hypothesis of cestode development, together with recent advances in phylogenetics, genomics, culture methods, and comparative analysis of cESTode gene expression that should encourage the incorporation of these fascinating parasites into the first-line of evo-devo research. Expand
[Identification of proliferating cells in Taenia solium cysts].
TLDR
A stable cell line of neoblasts would be useful for systematic in vitro studies on drug efficacy and the biology of T. solium, which causes human taeniasis and cysticercosis in humans and pigs. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 160 REFERENCES
Neuronal signal substances in asexual multiplication and development in flatworms
TLDR
Immunocytochemical studies of the changes in the flatworm neuroanatomy show that the nervous system, particularly the main never cords, has a central role during asexual development and a correlation between these two phenomena is suggested. Expand
Asexual reproduction and regeneration ofCatenula (Turbellaria, Archoophora)
TLDR
A theoretical model of the mechanisms controlling paratomy and regeration of Catenula, a turbellarian of the order Catenulida, shows that dedifferentiation plays some role in each of the processes examined. Expand
Stem cells in a basal bilaterian
TLDR
A comparison of the stem-cell pool in Acoela and higher platyhelminth species can provide evidence for the phylogenetic relationships of these taxa. Expand
Differentiation during asexual reproduction and regeneration in a microturbellarian
TLDR
It is proposed that neoblasts function both as stem cells for all differentiated cell types and as reserve cells with a determined life time in stem cells of Microstomum lineare. Expand
Interpretation of life history pattern in the Digenea.
  • W. C. Clark
  • Biology, Medicine
  • International journal for parasitology
  • 1974
TLDR
By dividing as infrequently as possible, consistent with the production of an adequate number of germinal cells, the lineage is preserved from the creation and incorporation of molecular errors, and thus the subsequent life history stages are protected from the incorporation of ‘senescence’ acquired at an earlier stage in the life history. Expand
Stem cells in microturbellarians
TLDR
It can be concluded that neoblasts function both as reserve cells and as functional stem cells for all differentiated cell types in these worms. Expand
Cytological approach to morphogenesis in the planarian blastema. II. The effect of neuropeptides.
  • I. Hori
  • Biology, Medicine
  • Journal of submicroscopic cytology and pathology
  • 1997
TLDR
The results of this study indicate that neuropeptides have a remarkable effect on the early stage of regeneration in planarians. Expand
Growth factors in asexually reproducing catenulida and macrostomida (Plathelminthes)?
TLDR
Antibodies to the growth factors EGF-r, EGF and bFGF as well as to the neuroactive substances 5-HT and RF-amide had a negative influence on the growth and asexual reproduction of culturedS. Expand
Regeneration and pattern formation in planarians. III. that neoblasts are totipotent stem cells and the cells
TLDR
This work describes a new approach to these problems regenerative and stem cell capabilities of purified differentiated cells when introduced, separately, into hosts. Expand
Primary anlage formation in diphyllobothriid tapeworms
TLDR
It is concluded that anlagen are formed by aggregation of germinative cells, which are located in the periphery of the periphery, mitosis being inhibited in the cells in the core. Expand
...
1
2
3
4
5
...