Flattening the Glucocorticoid Rhythm causes Changes in Hippocampal Expression of Messenger RNAs Coding Structural and Functional Proteins: Implications for Aging and Depression

@article{Gartside2003FlatteningTG,
  title={Flattening the Glucocorticoid Rhythm causes Changes in Hippocampal Expression of Messenger RNAs Coding Structural and Functional Proteins: Implications for Aging and Depression},
  author={Sarah Elizabeth Gartside and Melville M Leitch and Richard McQuade and Daniel J Swarbrick},
  journal={Neuropsychopharmacology},
  year={2003},
  volume={28},
  pages={821-829}
}
Subtle changes in glucocorticoid levels, including a flattening of the diurnal rhythm with raised nadir, are prevalent, being characteristic of both aging and major depression. Both these conditions are also associated with deficits in hippocampally mediated cognitive functions. We hypothesized that this profile of glucocorticoid levels causes structural and functional changes in the hippocampus, which in turn may engender cognitive deficits. We implanted slow-release corticosterone pellets… CONTINUE READING
11 Citations
61 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 11 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 61 references

Effects of gender and age on the levels and circadian rhythmicity of plasma cortisol

  • E Van Cauter, R Leproult, DJ Kupfer
  • J Clin Endocrinol Metab 81: 2468–2473.
  • 1996
Highly Influential
3 Excerpts

Similar Papers

Loading similar papers…