Flashback to the 1960s: utility of archived sera to explore the origin and evolution of Plasmodium falciparum chloroquine resistance in the Pacific.

@article{Chan2006FlashbackTT,
  title={Flashback to the 1960s: utility of archived sera to explore the origin and evolution of Plasmodium falciparum chloroquine resistance in the Pacific.},
  author={C W Chan and Daniel Lynch and Rita Spathis and Francis Wanak Hombhanje and Akira Kaneko and Ralph M. Garruto and Jeffery K Lum},
  journal={Acta tropica},
  year={2006},
  volume={99 1},
  pages={15-22}
}
The increasing frequencies of Plasmodium falciparum strains that are resistant to chloroquine (CQ) and other antimalarials are resulting in a global resurgence of malaria morbidity and mortality. CQ resistance (CQR) is associated with multiple mutations in the P. falciparum chloroquine resistance transporter (pfcrt) gene. The mode and tempo of the… CONTINUE READING