Flashback: Psychiatric Experimentation with LSD in Historical Perspective

  title={Flashback: Psychiatric Experimentation with LSD in Historical Perspective},
  author={Erika Dyck},
  journal={The Canadian Journal of Psychiatry},
  pages={381 - 388}
  • E. Dyck
  • Published 1 June 2005
  • Psychology
  • The Canadian Journal of Psychiatry
In the popular mind, d-lysergic acid diethylamide (LSD) research in psychiatry has long been associated with the CIA-funded experiments conducted by Ewen Cameron at the Allen Memorial Institute in Montreal, Quebec. Despite this reputation, a host of medical researchers in the post–World War II era explored LSD for its potential therapeutic value. Some of the most widespread trials in the Western world occurred in Saskatchewan, under the direction of psychiatrists Humphry Osmond (in Weyburn) and… 

Beringer ’ s experiential model of psychosis The idea of mimicking a mental disorder by administering a drug goes back to the French psychiatrist

The history of the concept and practice of model psychosis is examined in order to demarcate the peculiarities of its most recent articulation in the vocabulary of cognitive neuroscience and highlights the shift from phenomenological to biological psychiatry.

Do Hallucinogens Have a Role in the Treatment of Addictions? A Review of the Current Literature

Though more robust research is needed before use of these drugs can be effectively adopted into clinical practice, the current data is promising and suggests the potential for a new and unique avenue for the treatment of addiction.

Beyond LSD: A Broader Psychedelic Zeitgeist during the Early to Mid-20th Century

It is argued that while the discovery of LSD may have been a catalyst for psychedelic research in the 1950s and ‘60s, there was a broader psychedelic zeitgeist that deserves acknowledgement for setting the stage.

The Psychedelic Renaissance and Its Forensic Implications

  • B. Holoyda
  • Psychology
    The Journal of the American Academy of Psychiatry and the Law
  • 2020
Basic information that the forensic practitioner should know about psychedelic substances, including their various effects and proposed mechanism of action are summarized; historical and recent research into psychedelics and criminal behavior are described; and a practical means by which to assess individuals' psychedelic use in forensic contexts is offered.

Psychedelic-Assisted Psychotherapy: A Paradigm Shift in Psychiatric Research and Development

Mental disorders are rising while development of novel psychiatric medications is declining. This stall in innovation has also been linked with intense debates on the current diagnostics and

How to account for hallucinations in the interpretation of the antidepressant effects of psychedelics: a translational framework

A translational framework based on establishing pharmacokinetic/pharmacodynamic (PK/PD) relationships in rodents and humans for hallucinogenic and therapeutic effects will help to inform future studies that aim at the elucidation of the mechanism(s) of action of psychedelics in depression, and the role of the acute subjective and/or hallucinationsinogenic experience in their effects.

The History of Psychedelics in Psychiatry.

Increasing interest in a role for psychedelics as adjuncts to psychotherapy began to evolve and became the major focus of work with psychedelics up to the present day.

New Paradigms of Old Psychedelics in Schizophrenia

There is a need to dig deeply into psychedelic neurobiology to uncover how psychedelics could best be used as scientific tools to benefit psychiatric disorders including schizophrenia.

Before Laboratory Life: Perry, Sullivan and the missed encounter between psychoanalysis and STS

This article explores the potential fruitfulness of an encounter between psychoanalysis and science and technology studies (STS) by examining Perry’s (The Human Nature of Science: Researchers at Work

Psychedelics in the treatment of unipolar and bipolar depression

This is a narrative review about the role of classic and two atypical psychedelics in the treatment of unipolar and bipolar depression. Since the 1990s, psychedelics experience a renaissance in



Lysergic Acid Diethylamide (LSD) in the Treatment of Alcoholism: An Investigation of Its Effects on Drinking Behavior, Personality Structure, and Social Functioning

This latest volume on LSD therapy gives a very brief, yet scholarly review of the neurophysiological, behavioral, and psychological effects of LSD as well as proposed mechanisms of action, assesses previous therapeutic work with LSD, weighs it in the balance, and finds it wanting.

Some reflections on the possible therapeutic effects of the hallucinogens; with special reference to alcoholism.

  • C. Smith
  • Psychology, Medicine
    Quarterly journal of studies on alcohol
  • 1959
The present paper is an attempt to examine the nature of these putative therapeutic effects of LSD-25 and mescaline and to evaluate the effectiveness of these hallucinogenic drugs.


  • H. Osmond
  • Psychology
    Annals of the New York Academy of Sciences
  • 1957
The field of inquiry is limited by a definition that will prevent workers in this field from being overwhelmed with an inconveniently large poition of the pharmacopoeia, and this rough and ready guide excludes morphine, cocaine, atropine, and their derivatives.

LSD, my problem child

Numerous accounts of the discovery of LSD have been published in English; none, unfortunately, have been completely accurate. Here, at last, the father of LSD details the history of his "problem

The Psychopharmacology of Hallucinogens

A controlled study of lysergide in the treatment of alcoholism. 1. The effects on drinking behavior.

These trials are characterized by a lack of the very control groups, follow-up procedures, and measures of change which would allow any valid statement about lysergide to be made.

Storming Heaven: LSD and the American Dream

"Storming Heaven" is a riveting history of LSD and its influence on American culture. Jay Stevens uses the "curious molecule" known as LSD as a kind of tracer bullet, illuminating one of postwar

Deviance and Medicalization: From Badness to Sickness

The book is c;xtmsivdy rekenad with citations to a variety of archival materials, primary litmame, and aubobiagraphical w m, as well as wdlm bo pmoml interviews conducted by the author.

From the New York Times Magazine

Tomorrow’s NY Times Magazine article (The Civil Heretic) on Freeman Dyson includes an unfortunate quote from me that may appear to be disparaging and ad hominem (something about bigger fish to fry).

Not God: A History of Alcoholics Anonymous

A fascinating, fast-moving, and authoritative account of the discovery and development of the program and fellowship that the authors know today as Alcoholics Anonymous.