Flares in chronic hepatitis B patients induced by the host or the virus? Relation to treatment response during Peg-interferon {alpha}-2b therapy.

@article{Flink2005FlaresIC,
  title={Flares in chronic hepatitis B patients induced by the host or the virus? Relation to treatment response during Peg-interferon \{alpha\}-2b therapy.},
  author={Hajo J. Flink and Dave Sprengers and Bettina E Hansen and Monika van Zonneveld and Rob A de Man and Solko W. Schalm and Harry L. A. Janssen},
  journal={Gut},
  year={2005},
  volume={54 11},
  pages={1604-9}
}
BACKGROUND AND AIMS Flares are a well known phenomenon during antiviral treatment for chronic hepatitis B. Little is known about the effect of flares on response. We investigated the timing and characteristics of flares, in relation to treatment response (hepatitis B e antigen loss). PATIENTS A total of 266 patients, participating in a global randomised controlled study, were assigned to 52 weeks of 100 mug pegylated (Peg)-interferon alpha-2b weekly, combined with either daily lamivudine 100… CONTINUE READING
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Pegylated interferon alpha-2b alone or in combination with lamivudine as the treatment for HBeAg-positive chronic hepatitis B

  • H Janssen, M Van Zonneveld, H Senturk, S Zeuzem, U Akarca, Y Cakaloglu
  • 2005
Highly Influential
12 Excerpts

Combined cytolytic and noncytolytic intrahepatic CD8 T-lymphocyte reactivity is important for response to antiviral therapy in chronic hepatitis B patients

  • TJ Tang, J Kwekkeboom, S Mancham, RS Binda, RA de Man, SW Schalm
  • Hepatology
  • 2003
Highly Influential
4 Excerpts

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