Flap endonuclease 1 is overexpressed in prostate cancer and is associated with a high Gleason score

@article{Lam2006FlapE1,
  title={Flap endonuclease 1 is overexpressed in prostate cancer and is associated with a high Gleason score},
  author={John S. Lam and David B. Seligson and Hong Yu and Ai Li and Mervi Eeva and Allan J. Pantuck and Gang Zeng and Steve Horvath and Arie S. Belldegrun},
  journal={BJU International},
  year={2006},
  volume={98}
}
To investigate the expression and potential clinical usefulness of structure‐specific flap endonuclease 1 (FEN‐1) in human primary prostate cancer using tissue microarray technology, as FEN‐1 was recently identified to be overexpressed in CL1.1, the most aggressive clone generated from the hormone‐refractory prostate cancer cell line CL1. 
Overexpression of Flap Endonuclease 1 Correlates with Enhanced Proliferation and Poor Prognosis of Non-Small-Cell Lung Cancer.
TLDR
Findings have indicated that overexpressed FEN1 represents a prognostic biomarker and potential therapeutic target for NSCLC treatment, which warrants further study. Expand
Biological and clinical significance of flap endonuclease-1 in triple-negative breast cancer: Support of metastasis and a poor prognosis
TLDR
FEN1 was associated with a highly invasive triple-negative breast cancer (TNBC) subtype in both breast cancer samples from the Oncomine database and from patients recruited into the study, and a new role for FEN1 in regulating TNBC invasion and metastasis was revealed. Expand
The prognostic significance of Flap Endonuclease 1 (FEN1) in breast ductal carcinoma in situ
TLDR
FEN1 high expression in DCIS was associated with aggressive and high-risk features including higher nuclear grade, larger tumour size, comedo type necrosis, hormonal receptors negativity, higher proliferation index and triple-negative phenotype and was not an independent predictor of local recurrence-free interval. Expand
Overexpression and Hypomethylation of Flap Endonuclease 1 Gene in Breast and Other Cancers
TLDR
It is shown that F EN1 is significantly up-regulated in multiple cancers and the aberrant expression of FEN1 is associated with hypomethylation of the CpG island within the FEN2 promoter in tumor cells. Expand
Flap endonuclease 1 is a promising candidate biomarker in gastric cancer and is involved in cell proliferation and apoptosis.
TLDR
The results indicate that FEN1 may be a promising biomarker for the diagnosis of gastric cancer and individual therapy and a positive correlation with the degree of differentiation is confirmed. Expand
Flap endonuclease 1 silencing is associated with increasing the cisplatin sensitivity of SGC‑7901 gastric cancer cells.
TLDR
A potential chemotherapeutic target is suggested, which exhibits enhanced sensitivity to CDDP following FEN1 silencing in SGC‑7901 cells via decreased survival and increased apoptosis. Expand
Flap endonuclease 1 (FEN1) as a novel diagnostic and prognostic biomarker for gastric cancer.
TLDR
High expression of FEN1 in GC could be a promising early diagnostic and independent prognostic biomarker for GC, according to the results. Expand
Identification of Flap endonuclease 1 as a potential core gene in hepatocellular carcinoma by integrated bioinformatics analysis
TLDR
Nine core genes associated with HCC development are identified, offering novel insight into HCC progression, including the aberrantly elevated FEN1, which may represent a potential biomarker for HCC diagnosis and treatment. Expand
FEN 1 is Overexpressed in Testis , Lung and Brain Tumors
Flap endonuclease 1 (FEN1) is a DNA replication/repair protein involved in Okazaki fragment processing, long-patch base excision repair, DNA doublestrand break repair and stalled replication forkExpand
Genomic and protein expression analysis reveals flap endonuclease 1 (FEN1) as a key biomarker in breast and ovarian cancer
TLDR
FEN1 is a promising biomarker in breast and ovarian epithelial cancer and is associated with poor breast cancer specific survival in univariate and multivariate analysis. Expand
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TLDR
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