Flanking sequences for the human intercellular adhesion molecule-1 NF-kappaB response element are necessary for tumor necrosis factor alpha-induced gene expression.

@article{Paxton1997FlankingSF,
  title={Flanking sequences for the human intercellular adhesion molecule-1 NF-kappaB response element are necessary for tumor necrosis factor alpha-induced gene expression.},
  author={L L Paxton and Ling Li and Virginia H. Secor and Janice L Duff and Shubhada M. Naik and Nakako Shibagaki and S. Wright Caughman},
  journal={The Journal of biological chemistry},
  year={1997},
  volume={272 25},
  pages={15928-35}
}
The regulated expression of intercellular adhesion molecule-1 (ICAM-1) by cytokines such as tumor necrosis factor alpha (TNF-alpha) plays an important role in inflammation and immune responses. Induction of ICAM-1 gene transcription by TNF-alpha has previously been shown to be dependent upon a region of the ICAM-1 5'-flanking sequences that contains a modified kappaB site. We demonstrate here that this modified kappaB site alone is insufficient for induction of transcription by TNF-alpha. Site… CONTINUE READING

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