Flaming Mitochondria: The Anti-inflammatory Drug Leflunomide Boosts Mitofusins.


Despite the significance of mitochondrial dynamics in many diseases, drugs that modulate it are lacking. In this issue of Cell Chemical Biology, Miret-Casals et al. (2018) use a phenotypic high-throughput screen to discover a pro-fusion role for the anti-inflammatory drug Leflunomide, paving the way to screen for mitochondrial pro-fusion drug candidates. 
DOI: 10.1016/j.chembiol.2018.02.014