Flagellum of Legionella pneumophila positively affects the early phase of infection of eukaryotic host cells.

@article{Dietrich2001FlagellumOL,
  title={Flagellum of Legionella pneumophila positively affects the early phase of infection of eukaryotic host cells.},
  author={Claudia Dietrich and Klaus Heuner and B C Brand and J{\"o}rg H Hacker and Michael Steinert},
  journal={Infection and immunity},
  year={2001},
  volume={69 4},
  pages={2116-22}
}
Legionella pneumophila, the etiologic agent of Legionnaires' disease, contains a single, monopolar flagellum which is composed of one major subunit, the FlaA protein. To evaluate the role of the flagellum in the pathogenesis and ecology of Legionella, the flaA gene of L. pneumophila Corby was mutagenized by introduction of a kanamycin resistance cassette. Immunoblots with antiflagellin-specific polyclonal antiserum, electron microscopy, and motility assays confirmed that the specific flagellar… CONTINUE READING

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Characterization of a macrophagespecific infectivity locus (milA) of Legionella pneumophila

  • O. S. Harb, Y. Abu Kwaik
  • Infect. Immun
  • 2000
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