Flagellum assembly and function during the Leishmania life cycle.

  title={Flagellum assembly and function during the Leishmania life cycle.},
  author={Eva Gluenz and Michael L. Ginger and Paul G McKean},
  journal={Current opinion in microbiology},
  volume={13 4},
During a complex digenetic life cycle flagellated Leishmania parasites alternate between promastigote and amastigote forms which differ significantly in cellular morphology and flagellum length. Recent studies have provided important new insights into mechanisms by which Leishmania regulate expression of genes required for flagellum assembly, and mechanisms used to modify flagellum length. While the critical role of the promastigote flagellum in parasite biology has long been appreciated, the… CONTINUE READING