Flagellin enhances tumor-specific CD8⁺ T cell immune responses through TLR5 stimulation in a therapeutic cancer vaccine model.

@article{Nguyen2013FlagellinET,
  title={Flagellin enhances tumor-specific CD8⁺ T cell immune responses through TLR5 stimulation in a therapeutic cancer vaccine model.},
  author={Chung Truong Nguyen and Seol Hee Hong and Jeong-Im Sin and Hong Van Dinh Vu and Kwangjoon Jeong and Kyoung Oh Cho and Satoshi Uematsu and Shizuo Akira and Shee Eun Lee and Joon Haeng Rhee},
  journal={Vaccine},
  year={2013},
  volume={31 37},
  pages={3879-87}
}
Tumor antigen (TA)-specific immunotherapy is an emerging approach for cancer treatment. Potent adjuvants are prerequisites to the immunotherapy for overcoming the low immunogenicity of TAs. We previously demonstrated that a bacterial flagellin, Vibrio vulnificus FlaB, has potent adjuvant activity in various vaccination models. In this study, we investigated whether the FlaB protein could be a potent adjuvant for a human papillomavirus 16 E6 and E7 (E6/E7) peptide-based anticancer immunotherapy… CONTINUE READING
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