Flagellar phase variation of Salmonella enterica serovar Typhimurium contributes to virulence in the murine typhoid infection model but does not influence Salmonella-induced enteropathogenesis.

@article{Ikeda2001FlagellarPV,
  title={Flagellar phase variation of Salmonella enterica serovar Typhimurium contributes to virulence in the murine typhoid infection model but does not influence Salmonella-induced enteropathogenesis.},
  author={J S Ikeda and Clare K Schmitt and Stephen C Darnell and Patricia R Watson and Jennie Bispham and Timothy S. Wallis and Dr. L. Weinstein and Eleanor S. Metcalf and Peter G. Adams and C. David O'Connor and Alison D. O'Brien},
  journal={Infection and immunity},
  year={2001},
  volume={69 5},
  pages={3021-30}
}
Although Salmonella enterica serovar Typhimurium can undergo phase variation to alternately express two different types of flagellin subunit proteins, FljB or FliC, no biological function for this phenomenon has been described. In this investigation, we constructed phase-locked derivatives of S. enterica serovar Typhimurium that expressed only FljB (termed locked-ON) or FliC (termed locked-OFF). The role of phase variation in models of enteric and systemic pathogenesis was then evaluated. There… CONTINUE READING
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