Fkbp52 regulates androgen receptor transactivation activity and male urethra morphogenesis.

  title={Fkbp52 regulates androgen receptor transactivation activity and male urethra morphogenesis.},
  author={Hanying Chen and Weidong Yong and Terry D Hinds and Zuocheng Yang and Yuhong Zhou and Edwin R. S{\'a}nchez and Weinian Shou},
  journal={The Journal of biological chemistry},
  volume={285 36},
Hypospadias is a common birth defect in humans, yet its etiology and pattern of onset are largely unknown. Recent studies have shown that male mice with targeted ablation of FK506-binding protein-52 (Fkbp52) develop hypospadias, most likely due to actions of Fkbp52 as a molecular co-chaperone of the androgen receptor (AR). Here, we further dissect the developmental and molecular mechanisms that underlie hypospadias in Fkbp52-deficient mice. Scanning electron microscopy revealed a defect in the… CONTINUE READING
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Fkbp52 and Hypospadias 27784 JOURNAL OF BIOLOGICAL CHEMISTRY

  • D. F. Smith, D. O. Toft
  • J. Biol. Chem. 10.1074/jbc.M110.156091
  • 2008
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