Fixed-tissue binding of fluorescein-conjugated concanavalin A to malignant melanomas versus nevi.

@article{Miller1984FixedtissueBO,
  title={Fixed-tissue binding of fluorescein-conjugated concanavalin A to malignant melanomas versus nevi.},
  author={Alastair R O Miller and Ronald J. Barr},
  journal={Journal of the American Academy of Dermatology},
  year={1984},
  volume={11 4 Pt 1},
  pages={620-4}
}
Concanavalin A (con A) is a plant-derived lectin that has the capability of agglutinating malignant cells in vitro. We studied the binding of fluorescein isothiocyanate-conjugated con A to formalin-fixed, paraffin-embedded malignant melanomas and nevocellular nevi. Both malignant melanoma cells and nevus cells emitted partial or circumferential, cytoplasmic rim, apple green fluorescence. There was no demonstrable difference between fluorescence distribution or intensity between the two groups… CONTINUE READING