Fixed-ratio combination oxycodone/naloxone compared with oxycodone alone for the relief of opioid-induced constipation in moderate-to-severe noncancer pain

@article{Simpson2008FixedratioCO,
  title={Fixed-ratio combination oxycodone/naloxone compared with oxycodone alone for the relief of opioid-induced constipation in moderate-to-severe noncancer pain},
  author={K. Simpson and P. Leyendecker and M. Hopp and S. M{\"u}ller-lissner and O. L{\"o}wenstein and J. de Andr{\'e}s and J. Troy Ferrarons and B. Bosse and B. Krain and T. Nichols and W. Kremers and K. Reimer},
  journal={Current Medical Research and Opinion},
  year={2008},
  volume={24},
  pages={3503 - 3512}
}
ABSTRACT Objective: Opioid therapy is frequently associated with treatment-limiting constipation. Naloxone is an opioid antagonist with low oral systemic bioavailability. This Phase III clinical trial assessed the safety and efficacy of an oral fixed-ratio combination of oxycodone prolonged-release (PR) and naloxone PR compared with oxycodone PR in relieving opioid-induced constipation. Study design: This double-blind, multicenter trial was conducted in specialist and primary care centers in… Expand
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