Fixed drug eruption caused by 8-chlorotheophylline in dramamine with clinical and histologic studies.

@article{Stritzler1960FixedDE,
  title={Fixed drug eruption caused by 8-chlorotheophylline in dramamine with clinical and histologic studies.},
  author={C. Stritzler and A. Kopf},
  journal={The Journal of investigative dermatology},
  year={1960},
  volume={34},
  pages={
          319-30
        }
}
The designation “fixed drug eruption'' was probably first used by Brocq (1), whose description may be briefly summarized as follows: Dusky red, later brownish plaques, with well-defined borders, and edematous or bullous centers, tending to recur at precisely the same site, leaving brown pigmented patches on healing. 
FIXED DRUG ERUPTION *
The enigma of fixed drug eruption has fascinated dermatologists for over eighty years. The clinical features and investigative studies suggest that many immunopathogenic mechanisms may be involved.Expand
Fixed drug eruption. A brief review.
TLDR
Fixed drug eruption is a distinctive variant of drug-induced dermatoses with characteristic recurrence at the same site of the skin or mucous membranes with characteristic pathogenetic mechanisms. Expand
FIXED DRUG ERUPTION DUE TO METHAQUALONE
  • M. Heng
  • Medicine
  • The Australasian journal of dermatology
  • 1986
TLDR
Findings, together with the pain which preceded the appearance of the clinical lesions, and the presence of many neutrophils in the dermal infiltrate, support the current theory of antibody‐dependent cytotoxic mechanisms in the pathogenesis of fixed drug eruptions. Expand
Urticaria and fixed drug eruption in a patient treated with griseofulvin.
TLDR
The appearance of urticaria and FDE in the same patient following treatment with griseofulvin is, it is believed, the first to be described in the literature. Expand
Fixed eruptions: causative drugs and challenge tests
TLDR
The drugs responsible for eighty‐six cases of fixed drug eruption have been identified, and in all but two were confirmed by challenge, and the main causative drugs were phenazones and barbiturates, which were the most frequent causative agents in the series. Expand
FIXED DRUG ERUPTION DUE TO CYCLIZINE
SUMMARY.— A case is reported of a fixed drug eruption due to cyclizine which had been taken for the prevention of travel sickness.
FIXED ERUPTION DUE TO IODIDE AND ANTIPYRINE.
  • H. Baker
  • Chemistry, Medicine
  • The British journal of dermatology
  • 1962
TLDR
Phases of unreactivity may occur lasting for weeks or months, during which time the patient is refractory to even large doses of the previously provocative drug, suggesting a particular agent. Expand
Provocation Tests in a Chlormezanone-Induced Fixed Drug Eruption
TLDR
Patch tests were performed in a suspected case of FDE due to chlormezanone on the patient's normal and prelesional skin with all ingested drugs whose concentrations were one and ten percent. Expand
Chlorhexidine mouthwash-induced fixed drug eruption. Case report and review of the literature.
TLDR
This article reports for the first time a hypersensitivity reaction in the form of fixed drug eruption after the use of a mouthwash containing chlorhexidine. Expand
Erythema multiforme bullosum caused by 9-bromofluorene.
  • C. Defeo
  • Medicine
  • Archives of dermatology
  • 1966
TLDR
College students in an organic chemistry laboratory preparing 9-bromofluorene from N -bromosuccinimide and fluorene developed erythema multiforme bullosum, a dermatitis which began on exposed areas but rapidly involved covered portions of the body. Expand
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References

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FIXED DRUG ERUPTIONS
TLDR
The definition of the term fixed so far as it applies to drug eruptions is restating and a compilation of the different types of fixed eruptions that have been reported, the various drugs and other agents considered responsible for them and some comments on the pathogenesis of such manifestations are submitted. Expand
DRUG ERUPTIONS: I. FIXED PHENOLPHTHALEIN ERUPTIONS
TLDR
All cutaneous manifestations due to substances used as medicaments regardless of whether they are synthetic or derived from nature, orWhether they are pure chemicals or mixtures are included. Expand
PHENOLPHTHALEIN DERMATITIS: AN EXPERIMENTAL STUDY INCLUDING REPRODUCTION OF THE ERUPTION IN SKIN TRANSPLANTS
TLDR
It has been said that no synthetic drug has been introduced which has not in isolated cases given rise to symptoms of intolerance associated with cutaneous manifestations, and present-day literature on the subject is largely concerned with the newer preparations, especially those of synthetic origin. Expand
EXPERIMENTAL ASPECT OF FIXED ERUPTION DUE TO ALURATE, A COMPOUND OF ALLONAL
TLDR
Since 1903, numerous hypnotics of the barbituric acid series 2 in which the ethyl groups are replaced by other alkyl or aryl radicals have been developed, including, among the more common ones, amytal (isoamylethylbarbituic acid), dial (diallylbarbiturics acid), neonal (N-butyletholbarbitURic acid, nostal) and pentobarbital sodium. Expand
Histochemical responses of human skin following ultraviolet irradiation.
TLDR
The earliest clinical evidence of a sunburn reaction in human skin is the development of erythema beginning approximately 4 hours after exposure to sufficient quantity of ultraviolet irradiation between .29 and .32 microns, then gradually fades, being supplanted by a suntan. Expand
Reactions with Drug Therapy
TLDR
This is an excellent little book and provides much essential information for all those interested in restoring these unfortunate patients to as normal a state as possible. Expand
The distribution of alkaline phosphatase in normal and pathologic human skin.
  • A. Kopf
  • Biology, Medicine
  • A.M.A. archives of dermatology
  • 1957
TLDR
The purpose of this work was to perform adequately controlled investigations in order to elucidate the distribution of AP in normal human skin and in 68 dermatologic conditions. Expand
Histopathology of the Skin
TLDR
Histopathology of the skin is studied in detail in order to establish a clear picture of the immune response to various types of injuries. Expand
HISTOPATHOLOGY OF THE SKIN
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