Fixed-dose trial of the single isomer SSRI escitalopram in depressed outpatients.

  title={Fixed-dose trial of the single isomer SSRI escitalopram in depressed outpatients.},
  author={William M. J. Burke and Ivan Gergel and Anjana Bose},
  journal={The Journal of clinical psychiatry},
  volume={63 4},
BACKGROUND Escitalopram is the single isomer responsible for the serotonin reuptake inhibition produced by the racemic antidepressant citalopram. The present randomized, double-blind, placebo-controlled, fixed-dose multicenter trial was designed to evaluate the efficacy and tolerability of escitalopram in the treatment of major depressive disorder. METHOD Outpatients with an ongoing DSM-IV major depressive episode (N = 491) were randomly assigned to placebo, escitalopram, 10 mg/day… CONTINUE READING
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