Five years' experience of prenatal diagnosis of cystic fibrosis in the former U.S.S.R.

@article{Baranov1992FiveYE,
  title={Five years' experience of prenatal diagnosis of cystic fibrosis in the former U.S.S.R.},
  author={Vladislav S. Baranov and V. N. Gorbunova and Tatanya E. Ivaschenko and Shwed NYu and N S Osinovskaya and T K Kascheeva and V. I. Lebedev and Alexander V. Mikhailov and V G Vakharlovsky and Tatyana V. Kuznetzova},
  journal={Prenatal diagnosis},
  year={1992},
  volume={12 7},
  pages={575-86}
}
From a total of 490 cystic fibrosis (CF) high-risk families under supervision (mostly Russian Slavs from the European part of the country), DNA data including both direct screening for some CF gene (CFTR) mutations (delF508, G551D and 1677delTA) and allelic polymorphism studies with tightly CF linked DNA markers were collected from 261 families. All full families (129) and 86 CF families with a decreased index child were found to be either fully (42 per cent) or partially (40 per cent… CONTINUE READING