Five-year update of a randomized trial of alternating radiotherapy and chemotherapy compared with radiotherapy alone in treatment of unresectable squamous cell carcinoma of the head and neck.

@article{Merlano1996FiveyearUO,
  title={Five-year update of a randomized trial of alternating radiotherapy and chemotherapy compared with radiotherapy alone in treatment of unresectable squamous cell carcinoma of the head and neck.},
  author={Marco Carlo Merlano and Marco Benasso and Renzo Corv{\`o} and Ra{\'u}l Espinosa Rosso and Vito Vitale and Fernando Machado Blengio and Gianmauro Numico and Giovanni Margarino and Luigina Ada Bonelli and Leonardo Santi},
  journal={Journal of the National Cancer Institute},
  year={1996},
  volume={88 9},
  pages={
          583-9
        }
}
BACKGROUND In 1992, we reported the first analysis of a randomized trial comparing alternating radiotherapy and chemotherapy with radiotherapy alone in the treatment of squamous cell carcinoma of the head and neck. The results of that 3-year analysis indicated that the combined treatment had superior efficacy. PURPOSE After an additional 2 years of follow-up, we again compared the efficacy of the two treatment regimens, with attention paid to differences in overall survival, progression-free… CONTINUE READING

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