Five-year results of a randomized clinical trial comparing total mastectomy and segmental mastectomy with or without radiation in the treatment of breast cancer.

@article{Fisher1985FiveyearRO,
  title={Five-year results of a randomized clinical trial comparing total mastectomy and segmental mastectomy with or without radiation in the treatment of breast cancer.},
  author={Bernard Fisher and Madeline J. Bauer and Richard G. Margolese and Raymond Poisson and Yosef H. Pilch and Carol Redmond and Edwin R. Fisher and Norman Wolmark and Melvin M Deutsch and E D Montague},
  journal={The New England journal of medicine},
  year={1985},
  volume={312 11},
  pages={665-73}
}
In 1976 we began a randomized trial to evaluate breast conservation by a segmental mastectomy in the treatment of Stage I and II breast tumors less than or equal to 4 cm in size. The operation removes only sufficient tissue to ensure that margins of resected specimens are free of tumor. Women were randomly assigned to total mastectomy, segmental mastectomy alone, or segmental mastectomy followed by breast irradiation. All patients had axillary dissections, and patients with positive nodes… CONTINUE READING
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