Five stages of progressive β-cell dysfunction in the laboratory Nile rat model of type 2 diabetes.

@article{Yang2016FiveSO,
  title={Five stages of progressive β-cell dysfunction in the laboratory Nile rat model of type 2 diabetes.},
  author={Kaiyuan Yang and Jonathan Gotzmann and Sharee L Kuny and Hui Huang and Yves Sauv{\'e} and Catherine B Chan},
  journal={The Journal of endocrinology},
  year={2016},
  volume={229 3},
  pages={343-56}
}
We compared the evolution of insulin resistance, hyperglycemia, and pancreatic β-cell dysfunction in the Nile rat (Arvicanthis niloticus), a diurnal rodent model of spontaneous type 2 diabetes (T2D), when maintained on regular laboratory chow versus a high-fiber diet. Chow-fed Nile rats already displayed symptoms characteristic of insulin resistance at 2 months (increased fat/lean mass ratio and hyperinsulinemia). Hyperglycemia was first detected at 6 months, with increased incidence at 12… CONTINUE READING
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