Five percent CO₂ is a potent, fast-acting inhalation anticonvulsant.

  title={Five percent CO₂ is a potent, fast-acting inhalation anticonvulsant.},
  author={Else Tolner and Daryl W. Hochman and Pekka Hassinen and Jakub Ot{\'a}hal and Eija Gaily and Michael M Haglund and Hana Kubov{\'a} and Sebastian Schuchmann and Sampsa Vanhatalo and Kai Kaila},
  volume={52 1},
PURPOSE CO₂ has been long recognized for its anticonvulsant properties. We aimed to determine whether inhaling 5% CO₂ can be used to suppress seizures in epilepsy patients. The effect of CO₂ on cortical epileptic activity accompanying behavioral seizures was studied in rats and nonhuman primates, and based on these data, preliminary tests were carried out in humans. METHODS   In freely moving rats, cortical afterdischarges paralleled by myoclonic convulsions were evoked by sensorimotor cortex… CONTINUE READING
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