Five novel mono-tetrahydrofuran ring acetogenins from the seeds of Annona muricata.

@article{Rieser1996FiveNM,
  title={Five novel mono-tetrahydrofuran ring acetogenins from the seeds of Annona muricata.},
  author={M J Rieser and Zhe Ming Gu and X. P. Fang and Longmei Zeng and Karl Vernon Wood and Jerry McLaughlin},
  journal={Journal of natural products},
  year={1996},
  volume={59 2},
  pages={
          100-8
        }
}
Bioactivity-directed fractionation of the seeds of Annona muricata L. (Annonaceae) resulted in the isolation of five new compounds: cis-annonacin (1), cis-annonacin-10-one (2), cis-goniothalamicin (3), arianacin (4), and javoricin (5). Three of these (1-3) are among the first cis mono-tetrahydrofuran ring acetogenins to be reported. NMR analyses of published model synthetic compounds, prepared cyclized formal acetals, and prepared Mosher ester derivatives permitted the determinations of… CONTINUE READING

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