Five new blood group systems – what next?

@article{Storry2014FiveNB,
  title={Five new blood group systems – what next?},
  author={Jill R. Storry},
  journal={ISBT Science Series},
  year={2014},
  volume={9}
}
  • J. Storry
  • Published 1 July 2014
  • Biology
  • ISBT Science Series
At the meeting of the ISBT working party for red cell immunogenetics and blood group nomenclature in 2012, FORS, JR and LAN were ratified as blood group systems. Since then, the molecular basis of the Vel blood group antigen has been elucidated, and the complement regulator protein, CD59 has been shown itself to be a blood group antigen. These last two discoveries will no doubt lead to their elevation to blood group systems. How has this happened? It turns out to be a mixture of old and new… 
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References

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TLDR
The biochemical and genetic basis of the Vel blood group antigen, which has been a vexing mystery for decades, is reported and two highly specific DNA‐based tests for rapid Vel genotyping, which can be easily integrated into blood group genotypesing platforms are developed.
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TLDR
The first conclusive description of Fs expression in normal human hematopoietic tissue is provided and the basis of a new histo-blood group system in man, FORS is provided.
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In an attempt to detect weak sub-groups of A, the blood grouping protocols of more than 158,000 individual, volunteer blood donors were scanned after their first donation; all had been grouped a t
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TLDR
This book describes Karl Landsteiner’s seminal discovery and its background and includes, among other beautiful illustrations, a wonderful portrait of the young scientist.
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TLDR
The ABCG2 gene encodes antigens of the JR blood group system and some RBCs have been defined as Jr(a+W/–) or Jr( a–), particularly when tested with polyclonal anti‐Jra, in an effort to resolve apparent serologic ambiguities.
ABCB6 is dispensable for erythropoiesis and specifies the new blood group system Langereis
TLDR
ABCB6 is identified as the genetic basis of the Lan blood group antigen expressed on red blood cells but also at the plasma membrane of hepatocellular carcinoma (HCC) cells, and it is established that ABCB6 encodes a new blood group system.
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TLDR
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TLDR
Jra (ISBT 901005) is a high‐prevalence antigen unassigned to a blood group system that encode the Jr(a–) phenotype and these studies provided the impetus to study other Jr( a−) individuals.
Null alleles of ABCG2 encoding the breast cancer resistance protein define the new blood group system Junior
TLDR
It is reported here thatABCG2 comprises the molecular basis of a new blood group system (Junior, Jr) and that individuals of the Jr(a−) blood type have inherited two null alleles of ABCG2.
Homozygosity for a null allele of SMIM1 defines the Vel-negative blood group phenotype
TLDR
SNP profiling and transcriptional network modeling are combined to link the Vel-negative phenotype to SMIM1, located in a 97-kb haplotype block on chromosome 1p36, and this gene encodes a previously undiscovered, evolutionarily conserved transmembrane protein expressed on RBCs, establishingSMIM1 as anew erythroid gene and Vel as a new blood group system.
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