Five new blood group systems – what next?

  title={Five new blood group systems – what next?},
  author={Jill R. Storry},
  journal={ISBT Science Series},
  • J. Storry
  • Published 1 July 2014
  • Biology
  • ISBT Science Series
At the meeting of the ISBT working party for red cell immunogenetics and blood group nomenclature in 2012, FORS, JR and LAN were ratified as blood group systems. Since then, the molecular basis of the Vel blood group antigen has been elucidated, and the complement regulator protein, CD59 has been shown itself to be a blood group antigen. These last two discoveries will no doubt lead to their elevation to blood group systems. How has this happened? It turns out to be a mixture of old and new… 
Bioinformatic studies of genetic variation at known, novel and candidate blood group loci
The use of bioinformatic methods in the search of genetic variation at loci underlying human blood group systems and antigens was successful and the benefits of utilizing publicly available genotyping data in studies of blood groups are highlighted.
FORS, a new histo-blood group: A current review
It’s extremely important the study of this histo-blood group is carried out, considering all its potentialities, contributing to a better characterization of this Histo- blood group.
A delayed and acute hemolytic transfusion reaction mediated by anti-c in a patient with variant RH alleles
This case report describes a patient with variant RHD*DAR alleles inherited in conjunction with two compound heterozygote RHCE*ceEK/RHCE*ar alleles, which resulted in a suspected acute hemolytic transfusion reaction and the subsequent identification of anti-c.
Clinical significance of antibodies to antigens in the Raph, John Milton Hagen, I, Globoside, Gill, Rh-associated glycoprotein, FORS, JR, LAN, Vel, CD59, and Augustine blood group systems
Information on the clinical significance of antibodies to antigens in the Raph, John Milton Hagen, I, Globoside, Gill, Rh-associated glycoprotein, FORS, JR, LAN, Vel, CD59, and Augustine blood group systems is reviewed.
Screening for the SMIM1*64_80 del Allele in blood donors in a population from Southern Brazil
To evaluate the deletion of 17 bp in the SMIM1 gene in a population from the south of Brazil, 448 unrelated blood donors from 7 regions comprising the haemotherapy network in the state of Santa Catarina were evaluated between August 2011 and March 2014.
Hematologic complications in a patient with Glycine soja polyagglutination following fresh frozen plasma transfusion
The patient’s confounding hematologic complications can best be explained by polyagglutination, which developed secondary to the severe MRSA infection, and needs to be recognized to appropriately manage hemotherapy.
Evaluation of an amino acid residue critical for the specificity and activity of human Gb3/CD77 synthase
Stably transfected cells with vectors encoding Gb3/CD77 synthase with glutamine substituted by aspartic acid or asparagine and evaluated the cells by quantitative flow cytometry, high-performance thin-layer chromatography and real-time PCR affords a new insight into the mechanism of action of the human Gb 3/CD 77 synthase.
The Vel blood group system: a review
While screening for Vel– blood donors has become easier, the function of SMIM1 is still unknown, and despite its well-conserved sequence across the animal kingdom, the enigma continues.


Disruption of SMIM1 causes the Vel− blood type
The biochemical and genetic basis of the Vel blood group antigen, which has been a vexing mystery for decades, is reported and two highly specific DNA‐based tests for rapid Vel genotyping, which can be easily integrated into blood group genotypesing platforms are developed.
Forssman expression on human erythrocytes: biochemical and genetic evidence of a new histo-blood group system.
The first conclusive description of Fs expression in normal human hematopoietic tissue is provided and the basis of a new histo-blood group system in man, FORS is provided.
A New Variant of Blood Group A
In an attempt to detect weak sub-groups of A, the blood grouping protocols of more than 158,000 individual, volunteer blood donors were scanned after their first donation; all had been grouped a t
The Discovery and Significance of the Blood Groups
This book describes Karl Landsteiner’s seminal discovery and its background and includes, among other beautiful illustrations, a wonderful portrait of the young scientist.
The JR blood group system: identification of alleles that alter expression
The ABCG2 gene encodes antigens of the JR blood group system and some RBCs have been defined as Jr(a+W/–) or Jr( a–), particularly when tested with polyclonal anti‐Jra, in an effort to resolve apparent serologic ambiguities.
ABCB6 is dispensable for erythropoiesis and specifies the new blood group system Langereis
ABCB6 is identified as the genetic basis of the Lan blood group antigen expressed on red blood cells but also at the plasma membrane of hepatocellular carcinoma (HCC) cells, and it is established that ABCB6 encodes a new blood group system.
International Society of Blood Transfusion Working Party on red cell immunogenetics and blood group terminology: Berlin report
This study presents a large number of cases from across Europe and Asia that show clear trends in immune suppression in men and women over a long period of time, and these trends are likely to continue for some time to come.
The JR blood group system (ISBT 032): molecular characterization of three new null alleles
Jra (ISBT 901005) is a high‐prevalence antigen unassigned to a blood group system that encode the Jr(a–) phenotype and these studies provided the impetus to study other Jr( a−) individuals.
Null alleles of ABCG2 encoding the breast cancer resistance protein define the new blood group system Junior
It is reported here thatABCG2 comprises the molecular basis of a new blood group system (Junior, Jr) and that individuals of the Jr(a−) blood type have inherited two null alleles of ABCG2.
Homozygosity for a null allele of SMIM1 defines the Vel-negative blood group phenotype
SNP profiling and transcriptional network modeling are combined to link the Vel-negative phenotype to SMIM1, located in a 97-kb haplotype block on chromosome 1p36, and this gene encodes a previously undiscovered, evolutionarily conserved transmembrane protein expressed on RBCs, establishingSMIM1 as anew erythroid gene and Vel as a new blood group system.