Five furostanol saponins from fruits of Tribulus terrestris and their cytotoxic activities

  title={Five furostanol saponins from fruits of Tribulus terrestris and their cytotoxic activities},
  author={Jue Wang and Xuyu Zu and Yuyang Jiang},
  journal={Natural Product Research},
  pages={1436 - 1444}
Two new furostanol saponins, terrestroside A, 3-O-{β-D-xylopyranosyl-(1 → 3)-[β-D-xylopyranosyl(1 → 2)]-β-D-glucopyranosyl(1 → 4)-[α-L-rhamnopyranosyl(1 → 2)]-β-D-galactopyranosy}-26-O-β-D-glucopyranosyl-L-5a-furost-20(22)-en-(25R)-3β,26-diol (1) and terrestroside B, 3-O-{β-D-xylopyran-osyl(1 → 3)-[β-D-xylopyranosyl(1 → 2)]-β-D-glucopyranosyl(1 → 4)-[α-L-rhamnopyranosyl-(1 → 2)]-β-D-galactopyranosy}-26-O-β-D-glucopyranosyl-5a-furostan-12-one-(25R)-22-methoxy-3β,26-diol (2), together with three… 
Steroidal saponins from Tribulus terrestris.
A new furostanol saponin from Dendrobium chrysanthum Lindl. with cytotoxic activity
The inhibitory effects of the compounds on tumor cells were evaluated, and compounds 1–2 exhibited significant cytotoxic activities potentially against SPC-A1, MCF-7 and HeLa human cancer cell lines.
Pharmacochemistry Furostanol Glycosides from the Roots of Tribulus terrestris L .
A new furostanol glycoside was isolated from the roots of Tribulus terrestris growing in Georgia, together with four known furostanols. Their structures were elucidated by classical physical and
Analysis of variations in the contents of steroidal saponins in Fructus Tribuli during stir‐frying treatment
It is revealed that furostanol saponins with a C22-OH group could transform into corresponding furoStanol sap onins withA C-20-C-22 double bond (FSDB) via dehydroxylation, and FSDB could be successively converted into its secondary glycosides via a deglycosylation reaction.
The usage of plants, plant extracts or plant - derived pure chemicals for disease management, become a therapeutic modality, which has stood the test of time. In the present review, we focus on
Furostanol and Spirostanol Saponins from Tribulus terrestris
The structures of the new compounds were established on the basis of spectroscopic data, including 1D and 2D NMR and HRESIMS, and comparisons with published data.
Investigation on the toxic potential of Tribulus terrestris in vitro
T. terrestris had estrogenic and genotoxic activities and the study was useful in determining its toxicological effects and the precautions regarding consumption.
Cytotoxic and antitumor effects of Tribulus terrestris L fruit methanolic extract
The ascites tumor induced by EAC cells was found to be decreased considerably by the oral administration of the extract and the life span of the tumour bearing mice was enhanced to 31 and 45% by 100 and 250 mg/kg b.
Rapid Characterization of Constituents in Tribulus terrestris from Different Habitats by UHPLC/Q-TOF MS
It is demonstrated that this strategy provided an efficient protocol for the rapid identification of chemical constituents in complex samples such as traditional Chinese medicines (TCMs) by UHPLC/Q-TOF MSE with informatics platform.
Simultaneous Determination of 5 Flavonoids and 7 Saponins for Quality Control of Traditional Chinese Medicine Preparation Xinnaoshutong Capsule Using HPLC-VWD-ELSD
The developed HPLC-VWD-ELSD could be used as a rapid and reliable way in the assessment and quality control of XC and TT.


Steroidal saponins from fruits of Tribulus terrestris.
Terrestrinins A and B, two new steroid saponins from Tribulus terrestris
Two new steroid saponins, named terrestrinins A (1) and B (2), along with six known compounds were isolated from the Chinese medicine herb Tribulus terrestris, and their chemical structures were
Three new saponins from Tribulus terrestris.
Three new steroidal saponins 1-3, together with five known steroidal saponins, L-mannitol and an inorganic salt were isolated from Tribulus terrestris L. (Zygophyllaceae). The structures of the new
A New Steroidal Saponin from Tribulus Terrestris Linn
A new steroidal saponin containing six monosaccharides was obtained from the total plant of Tribulus terrestris and elucidated based on chemical spectroscopic analysis, especially on 2D-NMR
A New Steroidal Saponin from Chlorophytum malayense
A new steroidal saponin was isolated from the fresh rhizomes of Chlorophytum malayense, together with three known saponins, chloromaloside A-C, and the structure was elucidated as 26-O-beta-D-glucopyranosyl-22-hydroxy-25(S)-5alpha-furostan-12-oxo-3beta.
Biologically active steroidal glycosides from Tribulus terrestris.
Certain structural features are concluded to be required for these bioactivities of spirostanol-based steroidal saponins 1-3, which exhibited remarkable activity against fungal organisms and cancer cell lines.
Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays.
  • T. Mosmann
  • Biology
    Journal of immunological methods
  • 1983
The NMR study of a novel furostanol saponin from Tribulus terrestri
  • Chemical Journal of Chinese Universities,
  • 2002
Dictionary of Chinese herb medicines
  • 1977
Detection of proto-type compounds of diosgenin-and other spirostanol-glycosides.