Five fatal cases of serotonin syndrome after moclobemide-citalopram or moclobemide-clomipramine overdoses

  title={Five fatal cases of serotonin syndrome after moclobemide-citalopram or moclobemide-clomipramine overdoses},
  author={Pertti J. Neuvonen and Sinikka Pohjola-Sintonen and Ulrich Tacke and Erkki Vuori},
  journal={The Lancet},
Clinically–relevant anticancer-antidepressant drug interactions
The authors believe that epigenetic therapy combined with the rapid development of the semantic web can improve the scientific knowledge and lead to the development of new databases in the near future with novel strategies of detecting DDIs, so that the pharmaceutical care of cancer patients will ultimately be improved. Expand
The Pathophysiology of Serotonin Toxicity in Animals and Humans: Implications for Diagnosis and Treatment
This review primarily addresses the serotonin receptor subtypes that underlie the clinical manifestations of excess CNS serotonin in humans and animals, and their implications for diagnosis and treatment. Expand
Fatal serotonin syndrome: a systematic review of 56 cases in the literature
While fatal SS is rare, frequently observed features include hyperthermia, seizures, and high CK activities, and Cyproheptadine use appears infrequent for these patients. Expand
Revisited: Therapeutic and toxic blood concentrations of more than 1100 drugs and other xenobiotics
The data provided are useful for the therapeutic monitoring of pharmacotherapies, to facilitate the diagnostic assessment and monitoring of acute and chronic intoxications as well as to support forensic and clinical expert opinions. Expand
Psychopharmacological Treatment of Obsessive-Compulsive Disorder (OCD)
SSRI/clomipramine in combination with CBT/ERP is associated with the optimal response compared to each treatment alone or to other treatments, and the role of pharmacogenomics could become preponderant in the coming years. Expand
Concurrent Serotonin Syndrome and Hyponatremia: A Case Report and Review
Physicians should be aware of the probability of acute hyponatremia and serotonin syndrome secondary to SSRIs in simultaneous use of fluoxetine and buspirone with diuretics and note that serotonin toxicity is dose-dependent rather than idiosyncratic. Expand
Behandlung depressiver Störungen
In diesem Beitrag sollen die wesentlichen Kombinations- and Augmentationsstrategien bei depressiven Erkrankungen dargestellt werden. Expand
Duration of vaccine-induced immunity
Changes in vaccination schedules, particularly the prolongation of the booster intervals for some vaccine components, represents a challenge for veterinarians as well as for pet owners. For manyExpand
Fecava lecture * Top Ten Potential Drug Interactions in Small Animal Medicine
Today, comorbidities are increasingly diagnosed in veterinary patients and multiple drug combinations are common. However, as the number of administered drugs increases, so too does the risk forExpand


An update of recent moclobemide interaction data
  • J. Dingemanse
  • Chemistry, Medicine
  • International clinical psychopharmacology
  • 1993
In combination with therapeutic doses of either fluvoxamine or fluoxetine, moclobemide did not provide any indication of a serotoninergic syndrome, so that no wash-out period is needed when switching from a selective serotonin re-uptake inhibitor to moclOBemide or vice versa. Expand
Moclobemide overdose
Moclobemide is a recently introduced short-acting, selective and reversible monoamine oxidase inhibitor, type A, with few and mild side-effects at therapeutic doses, but combination with tricyclic antidepressants may result in serious poisoning. Expand
Serotonin syndrome caused by a moclobemide-clomipramine interaction.
A 7T year old woman with depression and Parkinson's disease has a case of serotonin syndrome induced by the reversible monoamine oxidase A inhibitor moclobemide and the serotonin reuptake inhibitor clomipramine, and fulfilled the diagnostic criteria for the serotonin syndrome suggested by Sternbach. Expand
The central nervous system serotonin syndrome
Clinical Pharmacology and Therapeutics (1993) 53, 84–88; doi:10.1038/clpt.1993.12
The serotonin syndrome.
  • H. Sternbach
  • Psychology, Medicine
  • The American journal of psychiatry
  • 1991
The serotonin syndrome is a toxic condition requiring heightened clinical awareness for prevention, recognition, and prompt treatment, and further work is needed to establish the diagnostic criteria, incidence, and predisposing factors. Expand