Five distinct deleted regions on chromosome 17 defining different subsets of human primary breast tumors.

@article{Nagai1995FiveDD,
  title={Five distinct deleted regions on chromosome 17 defining different subsets of human primary breast tumors.},
  author={Maria Aparecida Nagai and Andr{\'e}a Medeiros and Maria Mitzi Brentani and Ricardo Renzo Brentani and L Eduardo A Marques and Sylvie Mazoyer and Lois M Mulligan},
  journal={Oncology},
  year={1995},
  volume={52 6},
  pages={448-53}
}
In this study, we analyzed 105 paired sporadic primary breast tumor and normal tissue samples for loss of heterozygosity (LOH) on chromosome 17, using 12 polymorphic markers. We have identified partial or interstitial LOH in five separate regions of chromosome 17. Two of the deleted regions lie on the short arm of the chromosome, the first (region I, D17S5) in the telomeric part, distal to TP53 and the second spanning the TP53 gene (region II). Three of the five deleted regions lie on the long… CONTINUE READING
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