Five different anti-prostate-specific membrane antigen (PSMA) antibodies confirm PSMA expression in tumor-associated neovasculature.

@article{Chang1999FiveDA,
  title={Five different anti-prostate-specific membrane antigen (PSMA) antibodies confirm PSMA expression in tumor-associated neovasculature.},
  author={Stanley Shi-Chung Chang and Victor E. Reuter and Warren DeWayne Heston and Neil Harrison Bander and Lana S. Grauer and Paul B Gaudin},
  journal={Cancer research},
  year={1999},
  volume={59 13},
  pages={
          3192-8
        }
}
Prostate-specific membrane antigen (PSMA) is a type II integral membrane glycoprotein that was initially characterized by the monoclonal antibody (mAb) 7E11. PSMA is highly expressed in prostate secretory-acinar epithelium and prostate cancer as well as in several extraprostatic tissues. Recent evidence suggests that PSMA is also expressed in tumor-associated neovasculature. We examined the immunohistochemical characteristics of 7E11 and those of four recently developed anti-PSMA mAbs (J591… CONTINUE READING
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