Five-aminolevulinic acid for fluorescence-guided resection of recurrent malignant gliomas: a phase ii study.

@article{Nabavi2009FiveaminolevulinicAF,
  title={Five-aminolevulinic acid for fluorescence-guided resection of recurrent malignant gliomas: a phase ii study.},
  author={Arya Nabavi and Holger Thurm and Basilios Zountsas and Thorsten Pietsch and Heinrich Lanfermann and Uwe Pichlmeier and Maximilian Mehdorn},
  journal={Neurosurgery},
  year={2009},
  volume={65 6},
  pages={1070-6; discussion 1076-7}
}
OBJECTIVE To assess the feasibility of 5-aminolevulinic acid (5-ALA) fluorescence guidance for resection of recurrent malignant brain tumors. METHODS In a multicenter prospective, single-arm, uncontrolled phase II study, 36 patients with recurrent glioma (World Health Organization grade III/IV) received 5-ALA before surgery. After microsurgical resection, biopsies from pathological and nonpathological areas (as identified under conventional white light) were obtained to determine the positive… CONTINUE READING

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