Five-Year Analysis of the Prevention of Colorectal Sporadic Adenomatous Polyps Trial

@article{Arber2011FiveYearAO,
  title={Five-Year Analysis of the Prevention of Colorectal Sporadic Adenomatous Polyps Trial},
  author={Nadir Arber and Julius {\vS}pi{\vc}{\'a}k and Istv{\'a}n R{\'a}cz and Miroslav Zavoral and Aurora Breazna and Paola Gerletti and Maria Jos{\'e} Lechuga and Neal Collins and Rebecca B Rosenstein and Craig J. Eagle and Bernard Levin},
  journal={The American Journal of Gastroenterology},
  year={2011},
  volume={106},
  pages={1135-1146}
}
OBJECTIVES:Subjects in the Prevention of Colorectal Sporadic Adenomatous Polyps (PreSAP) trial (PRESAP/NCT00141193/www.clinicaltrials.gov) were studied to determine efficacy and safety at a year 5 assessment.METHODS:In this randomized, placebo-controlled, double-blind trial, 1,561 subjects with diagnosed colorectal adenomas removed within 3 months of the study's initiation were assessed after ∼3 years on celecoxib followed by 2 years off. Studied in 107 primary and secondary care settings… CONTINUE READING