Fitness of antibiotic-resistant microorganisms and compensatory mutations

@article{Bttger1998FitnessOA,
  title={Fitness of antibiotic-resistant microorganisms and compensatory mutations},
  author={Erik C B{\"o}ttger and Burkhard Springer and Michel Pletschette and Peter T. Sander},
  journal={Nature Medicine},
  year={1998},
  volume={4},
  pages={1343-1344}
}
come of different selections indicates that it is important to investigate clinical isolates with drug resistance or to use relevant animal models to investigate which of the possible resistance mutations are selected under in vivo conditions. A high level of selection for drug-resistance mutations without involving the cost of decreased fitness would seem to exist in vivo. These results argue against the belief that compensatory mutations are of clinical relevance, at least for drug resistance… CONTINUE READING

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