Fitness of RNA virus decreased by Muller's ratchet

@article{Chao1990FitnessOR,
  title={Fitness of RNA virus decreased by Muller's ratchet},
  author={L. Chao},
  journal={Nature},
  year={1990},
  volume={348},
  pages={454-455}
}
  • L. Chao
  • Published 1990
  • Biology, Medicine
  • Nature
WHY sex exists remains an unsolved problem in biology1–3. If mutations are on the average deleterious, a high mutation rate can account for the evolution of sex4. One form of this mutational hypothesis is Muller's ratchet5,6. If the mutation rate is high, mutation-free individuals become rare and they can be lost by genetic drift in small populations. In asexual populations, as Muller5 noted, the loss is irreversible and the load of deleterious mutations increases in a ratchet-like manner with… Expand
462 Citations
Evolution of sex and the molecular clock in RNA viruses.
  • 45
MULLER'S RATCHET AND THE ADVANTAGE OF SEX IN THE RNA VIRUS ϟ6
  • 107
Rare beneficial mutations can halt Muller's ratchet
  • 4
  • PDF
Searching for the Advantages of Virus Sex
  • P. Turner
  • Biology, Medicine
  • Origins of life and evolution of the biosphere
  • 2004
  • 20
  • PDF
Sexual reproduction and Muller's ratchet in digital organisms
  • 13
  • PDF
Finite genome size can halt Muller's ratchet
  • PDF
Drastic Fitness Loss in Human Immunodeficiency Virus Type 1 upon Serial Bottleneck Events
  • 157
  • Highly Influenced
  • PDF
Muller's Ratchet and compensatory mutation in Caenorhabditis briggsae mitochondrial genome evolution
  • 76
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 16 REFERENCES
Evolution of sex in RNA viruses.
  • L. Chao
  • Biology, Medicine
  • Journal of theoretical biology
  • 1988
  • 57
QUANTITATIVE VARIATION IN FINITE PARTHENOGENETIC POPULATIONS: WHAT STOPS MULLER'S RATCHET IN THE ABSENCE OF RECOMBINATION?
  • G. Wagner, W. Gabriel
  • Biology, Medicine
  • Evolution; international journal of organic evolution
  • 1990
  • 86
  • PDF
The evolutionary advantage of recombination.
  • 1,359
  • PDF
Isolation of nonsense suppressor mutants in Pseudomonas.
  • 126
  • PDF
Deleterious mutations and the evolution of sexual reproduction
  • 1,042
Rapid evolution of RNA genomes.
  • 1,240
...
1
2
...