Fitness flux and ubiquity of adaptive evolution.

@article{Mustonen2010FitnessFA,
  title={Fitness flux and ubiquity of adaptive evolution.},
  author={Ville Mustonen and Michael L{\"a}ssig},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2010},
  volume={107 9},
  pages={4248-53}
}
Natural selection favors fitter variants in a population, but actual evolutionary processes may decrease fitness by mutations and genetic drift. How is the stochastic evolution of molecular biological systems shaped by natural selection? Here, we derive a theorem on the fitness flux in a population, defined as the selective effect of its genotype frequency changes. The fitness-flux theorem generalizes Fisher's fundamental theorem of natural selection to evolutionary processes including… CONTINUE READING
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