Fitness cost of antibiotic susceptibility during bacterial infection

@article{Roux2015FitnessCO,
  title={Fitness cost of antibiotic susceptibility during bacterial infection},
  author={Damien Roux and Olga Danilchanka and Thomas Guillard and Vincent Cattoir and Hugues Aschard and Yang Fu and François Angoulvant and Jonathan Messika and J D Ricard and John J Mekalanos and Stephen Lory and Gerald B Pier and David Skurnik},
  journal={Science Translational Medicine},
  year={2015},
  volume={7},
  pages={297ra114-297ra114}
}
Advances in high-throughput DNA sequencing allow for a comprehensive analysis of bacterial genes that contribute to virulence in a specific infectious setting. Such information can yield new insights that affect decisions on how to best manage major public health issues such as the threat posed by increasing antimicrobial drug resistance. Much of the focus has been on the consequences of the selective advantage conferred on drug-resistant strains during antibiotic therapy. It is thought that… CONTINUE READING
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