Fitness cost of VanA-type vancomycin resistance in methicillin-resistant Staphylococcus aureus.

@article{Foucault2009FitnessCO,
  title={Fitness cost of VanA-type vancomycin resistance in methicillin-resistant Staphylococcus aureus.},
  author={Marie-Laure Foucault and Patrice Courvalin and Catherine Grillot-Courvalin},
  journal={Antimicrobial agents and chemotherapy},
  year={2009},
  volume={53 6},
  pages={2354-9}
}
We have quantified the biological cost of VanA-type glycopeptide resistance due to the acquisition of the resistance operon by methicillin-resistant Staphylococcus aureus (MRSA) from Enterococcus sp. Exponential growths of recipient strain HIP11713, its transconjugant VRSA-1, VRSA-5, and VRSA-6 were compared in the absence or, except for HIP11713, in the presence of vancomycin. Induction of resistance was performed by adding vancomycin in both the preculture and the culture or the culture at… CONTINUE READING
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