Fitness consequences of a regulatory polymorphism in a seasonal environment.

@article{Suiter2003FitnessCO,
  title={Fitness consequences of a regulatory polymorphism in a seasonal environment.},
  author={Amy M. Suiter and Otmar B{\"a}nziger and Antony M Dean},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2003},
  volume={100 22},
  pages={12782-6}
}
Gene regulation is commonly assumed to have evolved in response to environmental variability. Although tightly regulated in Escherichia coli strain K12, transcriptional control of arginine biosynthesis is deregulated in strain B. Caused by a single amino acid replacement in the arginine repressor, these contrasting regulatory strategies result in a fitness tradeoff. The K12 repressor is selectively favored in the presence of arginine and disfavored in its absence. In environments that cycle… CONTINUE READING