Fitness comparison of thymidine analog resistance pathways in human immunodeficiency virus type 1.

@article{Hu2006FitnessCO,
  title={Fitness comparison of thymidine analog resistance pathways in human immunodeficiency virus type 1.},
  author={Zixin Hu and Francoise F. Giguel and Hiroyu Hatano and Patrick Reid and Jing Hua Lu and Daniel R. Kuritzkes},
  journal={Journal of virology},
  year={2006},
  volume={80 14},
  pages={7020-7}
}
Resistance to zidovudine (ZDV) results from thymidine analog resistance mutations (TAMs) at human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) codons 41, 67, 70, 210, 215, and 219. Two mutations are possible at codon 215: Y or F. Whereas T215Y occurs alone or with M41L and L210W (TAM-1 pattern), T215F rarely occurs with these mutations or by itself; it is found instead with D67N, K70R, and K219Q (TAM-2 pattern). The L210W mutation most often occurs with M41L and T215Y and… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 29 extracted citations

Similar Papers

Loading similar papers…